Hey, need help with a rubbish assignment

major prognostic factors in Breast Cancer (no subtype..general)….Ive only got 1000 words

Obvious ones are grading, staging, blah blah

pathology is no problem

Having trouble with molecular markers

A look through the current journal articles reveal about a thousand proposed ones and I have to stick to the important ones given the 1000 word limit

so far ive pinpointed

Progesterone Receptors

Estrogen Receptors

HER2/neu

Im not sure about BRCA1 and 2…I know they are implicated genetically but does anyone know what prognostic value they have in terms of someone who has been diagnosed with BC

and has the gene as opposed to someone who has been diagnosed and doesnt

any other obvious ones Im missing

Replies requested only from bio/med students and doctors/researchers please

Thanks for any collaboration/confirmatio… you can give me on this. When it comes to research on BC it seems you really are spoilt for choice

cheer|||BRCA 1 is an inherited gene predisposing and increasing a persons risk of breast cancer above the average risk of a person w/o BRCA1. BRCA2 is inherited and increases both breast cancer and ovarian cancer risk much higher than normal. Ovarian cancers are still the most elusive to detect at an early stage and treat, thus much higher mortality rates. Persons w/BRCA 1 and BRCA 2 tend to get cancer at a younger age w/greater recurrence rates, 1st dxn. almost always under 50 yrs.