Okay, we know that PSA (Prostate Specific Antigen) is produced by prostate gland cells (the epithelium) hence it is reasonable to think that the cells will continue to manufacture PSA even if they are in locations outside the prostate? Having said that, does an elevated level of PSA in a prostate cancer patient in remission and with full/radical Prostatectomy indicates the presence of a metastatic tumor somewhere? If NOT how and why could the PSA levels be so elevated in the above described patient? Your informed comments will be greatly appreciated - Thank You.|||Because PSA is specific for prostate, I%26#039;d be very concerned about recurrence or metastasis.

There could have been invasion of the tumour that was missed, or early, previously undetected metastasis at the time of surgery.

My best to your friend… good luck with a bad disease.