A pathological manifestations: normal liver size, quality scans. The main feature is active fiber hyperplasia, a fiber beam sizes, renewable single nodule uneven, only a few false lobular form.
2, the functional performance: moderate liver dysfunction, such as: ALT, AST mildly elevated without jaundice, light to moderate reduce serum protein, serum - time pro normal, normal blood ammonia.
3, clinical symptoms: can no obvious clinical symptoms, also may be in the leans.
With the onset of cirrhosis than those in the general course of slow, insidious 3-5 years or more than 10 years ago, its clinical manifestations can be divided into decompensated liver function and the decompensated stage, but two boundaries is not obvious or overlap.
One, decompensated liver function lesser symptoms often lack specificity, the lack of fatigue, anorexia and dyspepsia based. There are nausea, repulsive oil, abdominal flatulence, abdominal discomfort, pain and diarrhea.
2, decompensated liver function symptoms significantly.
(1) Liver dysfunction clinical manifestations:
1. General systemic symptoms and poor nutritional status, weight loss fatigue, deep, severe, debilitating and bedridden. Rough dry skin, and leans gloomy dark complexion. Often anemia, anemia, nutritional, night blindness, and the swelling and Polyneuritis.
2. Gastrointestinal symptoms.
3. Bleeding and anemia.
4. Endocrine disorders.
(2) levy of portal hypertension clinical manifestations constitutes portal hypertension sign a three clinical manifestations splenomegaly, and the establishment of collateral circulation and open, ascites, have important clinical significance. Collateral circulation particularly the establishment and opening of the diagnosis of value.
Clinical manifestations of liver cirrhosis
General hepatitis and cirrhosis patients systemic symptoms, there are many performance features of the liver, different patients can be very different. In addition to the usual clinical manifestations of chronic hepatitis, its main clinical features of liver dysfunction and portal hypertension. But there are also some occult patients with cirrhosis without any clinical manifestations, even in laparotomy surgery, autopsy or other examination found.
(1) general symptoms
Typical patients and the general condition of both poor nutrition, weight loss, deep, poor appetite, self-induced fatigue weakness, abdominal distension and most of the afternoon and evening of the case, there are left and right quarter of help in pain or discomfort, the sense of falling, some patients have irregular fever, mouth Cape consciously, leads to weight, Jin Yi led to high-fat food such as diarrhea.
(2) symptoms and signs
1. Skin changes in some patients with pigmented leans filthy, there are stained. Superior vena cava in the drainage areas that spider Germany. Hands can be showed liver palms, telangiectasia also more common, mainly in the dry skin of patients with cirrhosis of the face and thigh-skin. Some patients with abdominal vein evident, and can re-shaped with varicose.
2. In the early cirrhosis of liver and spleen, liver enlargement can be advanced smaller, more hard and texture, surface and the price or distribution of small nodules. The liver size, hardness, surface is smooth, and the liver fatty infiltration and the number of liver regeneration, fibrous tissue hyperplasia and the extent of the contraction. The majority of patients with varying degrees of the license. Decompensated liver function generally levy no ascites.
3. Liver dysfunction clinical performance
(1) Huang yield: jaundice patients with cirrhosis of liver cells is more, the event should be considered: 1 indicated the activity of hepatitis diseases. ② intrahepatic cholestasis: cirrhosis, bile production and secretion of various aspects of the process could occur obstacles caused cholestasis. There are three main aspects: sodium-potassium ATPase dysfunction; Transporter cells inhibited; Liver cell membrane permeability changes. ③ serious liver function failure: Lesions often said to have developed end-stage, accompanied hepatic encephalopathy poor prognosis. ④ cirrhosis have occurred on the basis of malignant transformation: Depth should dramatically enhance tumor suspected hepatic portal transfer from biliary obstruction.
(2) tendency to bleeding and anemia: liver function decline on prothrombin and other coagulation factor synthesis; At the same time because of hypersplenism and bone marrow megakaryocyte void formation. Lead thrombocytopenia; Platelet membrane phospholipids, glycoprotein structure abnormal adhesion and aggregation and low, it often Purple epidemic, nose bleeding gums and gastrointestinal bleeding. Patients have varying degrees of anemia, and more from a lack of nutrition, poor intestinal absorption, hypersplenism and gastrointestinal bleeding and other factors.
(3) gastrointestinal symptoms: loss of appetite was diminished sense of abdominal discomfort after eating and guns bulging, flu can be severe nausea, vomiting or even the fat and protein tolerance of difference. For patients with ascites and gastrointestinal flu gas and abdominal distension, there will be advanced in the dark intestinal toxicity. Generation and the symptoms of gastrointestinal congestion, edema, inflammation caused by digestion and absorption of intestinal dysfunction and disorder-related groups. Also very common chronic cholecystitis, its symptoms and the symptoms of cirrhosis difficult to distinguish.